Other name(s):

vitamin B-1, thiamin (U.S. spelling), thiamine (European spelling)

General description

Thiamin is a part of the B family of vitamins (B complex). It was the first water-soluble vitamin discovered. It is also known as vitamin B-1. Like all B vitamins, thiamin is best known for helping make energy. Beriberi and Wernicke-Korsakoff syndrome are the most common diseases linked with thiamin deficiency. These diseases are not common in the U.S.

Thiamin is needed to turn glucose and carbohydrates into energy. It works with other enzymes in more than 20 metabolic processes.

Thiamin is also needed for the nervous system and the brain to work well. Low levels can lead to nerve problems because thiamin is needed for nerve function.

Medically valid uses

Thiamin is used to treat or prevent beriberi. It’s also used to treat Wernicke-Korsakoff syndrome (WKS). This is a severe thiamin deficiency. It’s caused by a low intake of and less ability to use thiamin. It’s common in people with any of these:

• Alcoholism

• A severe digestive disorder

• Fast-growing blood cancer

• Drug use disorders

• AIDS

• Weight-loss surgery

Unsubstantiated claims

There may be benefits that have not yet been proven through research.

Thiamin may repel mosquitoes. It may also lower blood sugar levels in people with diabetes. More studies are needed to see if thiamin supplements can lower glucose levels in people with diabetes. Or lessen problems from diabetes.

It may also help improve mental stability. It’s also been used to boost appetite. It may also treat rare metabolic issues related to learning disabilities.

Recommended intake

How much thiamin you need depends on how many calories from carbohydrates you get in your diet. The more carbohydrates you eat, the more thiamin you need. Thiamin is measured in milligrams (mg). Adults need about 0.4 mg to 0.5 mg for every 1,000 calories they eat.

The RDA in the chart below is the Recommended Dietary Allowance.

*Adequate Intake. This is based on the average intake in healthy, breastfed infants.

Thiamin is not stable at high temperatures. Because of this, cooking reduces its amount in food by 10% to 25%. Thiamin dissolves in water. So if you cook foods high in thiamin in water, try using the water in the food if possible. By discarding the water, you won’t get as much thiamin.

Using sulfur dioxide to preserve dried fruit will destroy the thiamin content.

Thiamin is sensitive to light. Store foods with thiamin in light-resistant containers.

Thiamin supplements may be needed for any of the below:

• People with alcoholism or heavy alcohol use

• People who eat diets high in refined carbohydrates

• Breastfed babies whose mothers have a poor diet

• People with hyperthyroidism

• People with hypermetabolic problems, such as pheochromocytoma

• People who have a lot of stress

• People doing a lot of heavy physical activity

• Women who are pregnant or breastfeeding. Talk with your healthcare provider first.

• Older adults with poor diets and natural decrease of absorption due to aging

Early symptoms of thiamin deficiency include:

• Loss of appetite

• Weight loss

• Weakness

• Severe tiredness (fatigue)

• Confusion

• Short-term memory loss

Later symptoms may include:

• Pain

• Numbness

• Tingling

• Muscle weakness

• Poor coordination

• Mood swings

• Irritability

• Depression

• Memory loss

The later stages of thiamin deficiency can turn into beriberi. This includes dry beriberi, wet beriberi, and Wernicke-Korsakoff syndrome.

Dry beriberi can cause nerve and muscle problems. It can cause peripheral nerve changes (polyneuritis). Symptoms of dry beriberi may include:

• Numbness and tingling of toes

• Burning feeling in feet

• Pain in the legs with muscle cramping and wasting (atrophy)

Wet beriberi is linked to cardiovascular disease. Symptoms can include:

• Swelling

• Increased heart rate

• Sweating

• Trouble breathing

• Enlarged heart

• Right-side heart failure

• Sudden death

Symptoms of Wernicke-Korsakoff syndrome include:

• Loss of memory

• Confusion between real and imagined memories

• Hallucinations

In the U.S., WKS is often linked with alcoholism. If the damage from WKS isn’t too bad, it can often be quickly reversed with thiamin. It can lead to coma and death if not treated.

Side effects, toxicity, and interactions

There are no known side effects of too much thiamin. Extra thiamin comes out in the urine.

You shouldn’t take thiamin if you’re allergic to it.

There are no known food interactions with thiamin.

Furosemide is a loop diuretic. It is used to treat edema and hypertension that may decrease thiamin levels. It does this by increasing urinary output.