What is biliary atresia in children?

Biliary atresia is a rare liver disease that occurs in newborn babies. It's often found shortly after birth. The disorder affects tubes in the liver called bile ducts. If not treated with surgery, it can be fatal.

Bile is a fluid made by the liver. Normally the bile ducts take bile to the small intestine. Bile helps with digestion and also carries waste products. When a child has biliary atresia, the bile ducts in the liver are blocked. Bile becomes backed up in the liver. This damages the liver. Many vital body functions also are affected.

There are 2 types of biliary atresia:

• Perinatal biliary atresia. This is the most common type. It appears after birth, most often when a baby is about 2 to 4 weeks old.

• Fetal biliary atresia. This is less common. It appears while a baby is still developing in the mother’s womb.

Biliary atresia must be treated with surgery. It's the most common cause of liver transplants in children in the U.S. It's more common in girls than in boys.

The dotted lines show areas that can be affected by biliary atresia.

What causes biliary atresia in a child?

Experts don’t know what causes biliary atresia. It's not passed down from parent to child, so it's not an inherited disease.

Researchers are looking at possible causes, such as:

• Viral or bacterial infections

• Immune system problems

• Genetic defect

• Exposure to toxins

Which children are at risk for biliary atresia?

Premature babies are at greater risk for biliary atresia than full-term infants. Asian and African-American babies are also at greater risk for the disorder.

What are the symptoms of biliary atresia in a child?

Babies with biliary atresia usually seem healthy at birth. Most often, symptoms start between 2 weeks and 2 months of life. Symptoms may include:

• Yellowish skin and eyes (jaundice)

• Dark urine

• Pale, almost white stools

• Swollen belly (abdomen)

• Weight loss

Symptoms of biliary atresia may look like other liver conditions or health problems. Always see your child's healthcare provider for a diagnosis.

How is biliary atresia diagnosed in a child?

Your child’s healthcare provider will give your child an exam and take a health history. The provider may also do several tests. These may include the following.

How is biliary atresia treated in a child?

Without surgery, biliary atresia can be fatal. Two types of surgery are used to treat this condition. Your child's healthcare provider will discuss which surgery would be a good choice for your child.

What are possible complications of biliary atresia in a child?

Biliary atresia causes liver damage and affects many processes that allow the body to work normally. Without surgery, the disease can be fatal.

Even after surgery, babies with biliary atresia are at risk for cholangitis, an infection of the bile ducts that can spread to the liver. This needs immediate treatment with IV (intravenous) antibiotics.

Malnutrition and failure to thrive are common in children with biliary atresia.

How can I help my child live with biliary atresia?

Before your child has surgery, nutrition may be a problem. With biliary atresia, not enough bile reaches the intestine to help digest fats in the diet. Liver damage can cause a lack of protein and a lack of vitamins. Children with liver disease need more calories than a normal child because they have a faster metabolism.

Your child’s healthcare provider may recommend that your child see a pediatric nutritionist. The nutritionist can advise you on your child's diet. A nutritional plan may include a balanced diet and added vitamins, as directed by your child’s healthcare provider.

Some children with liver disease become too sick to eat normally. If this is the case, your child’s provider may also recommend that you give high-calorie liquid feedings. These feedings are given through a tube called an NG (nasogastric) tube. The tube is guided into your child’s nose, down the esophagus, and into the stomach. A high-calorie liquid can be given through the tube to add to your child's diet if your child can only eat small amounts of food. Or it can replace meals if your child is too sick to eat.

After surgery, your child's digestion may go back to normal. Or you may still need to give your child extra vitamins or adjust your child's diet. Talk with your child's healthcare provider for recommendations.

Many factors affect how well children with biliary atresia do over time. These factors include:

• How much damage occurred to the bile ducts

• At what age the child had either a Kasai procedure or liver transplant

• How much liver damage has occurred

• The child’s overall health

After a liver transplant, your child's health will typically improve. But your child must follow a strict medical routine. This includes taking:

• Medicines to prevent the body’s immune system from attacking, or rejecting, the new liver. These are called antirejection medicines. They weaken the immune system’s response.

• Medicines to prevent infection, called antibiotics

• Other medicines may be prescribed, and some new medicines are being investigated to see if they help.

 It's important to work closely with your child's healthcare providers.

When should I call my child's healthcare provider?

Call your child’s healthcare provider right away if you see that your child has any of the following:

• Yellowish skin and eyes (jaundice)

• Very dark, almost brown-colored urine

• Pale, almost white stools

• Lack of weight gain

Also call your child’s healthcare provider to ask what symptoms you should look for if your child:

• Has been diagnosed with biliary atresia

• Has had surgery to correct the disorder

Key points about biliary atresia in children

• Biliary atresia is a rare liver disorder that occurs in newborn babies.

• Experts don’t know what causes the disease.

• If not treated with surgery, biliary atresia can be fatal.

• At some point, even with a diagnosis right away, surgery, and the best care, your child may need a liver transplant.

• After a liver transplant, your child must take medicines to stop the body from attacking, or rejecting, the new liver.

Next steps

Tips to help you get the most from a visit to your child’s healthcare provider:

• Know the reason for the visit and what you want to happen.

• Before your visit, write down questions you want answered.

• At the visit, write down the name of a new diagnosis and any new medicines, treatments, or tests. Also write down any new instructions your provider gives you for your child.

• Know why a new medicine or treatment is prescribed and how it will help your child. Also know what the side effects are.

• Ask if your child’s condition can be treated in other ways.

• Know why a test or procedure is recommended and what the results could mean.

• Know what to expect if your child does not take the medicine or have the test or procedure.

• If your child has a follow-up appointment, write down the date, time, and purpose for that visit.

• Know how you can contact your child’s provider after office hours. This is important if your child becomes ill and you have questions or need advice.