Changes in hormone levels, activity, medicines, or diet can affect the bone-making system. When the system gets out of balance, the amount of bone lost is greater than the amount of bone made. This can cause osteopenia. It is when bone starts to become less dense. Left untreated, bone loss gets worse, leading to osteoporosis. Weak bones can't support the body. In fact, they can break (fracture) just from the weight of your body. This often happens in bones of the spine (vertebrae). When vertebrae fracture, parts of the spine compress. This causes the back to bend or hump over, and it can also cause back pain.