Click a letter to see a list of conditions beginning with that letter.
Click 'Topic Index' to return to the index for the current topic.
Click 'Library Index' to return to the listing of all topics.
Immune Thrombocytopenic Purpura
What is immune thrombocytopenic purpura?
Immune thrombocytopenic purpura (ITP) is a blood disorder. With this disease, you have a lower amount of platelets than normal in your blood. Platelets are blood cell fragments that help with blood clotting. Having fewer platelets can cause easy bruising, bleeding gums, and internal bleeding. ITP is caused by an immune reaction against your own platelets. This means that your body’s immune system attacks your platelets by mistake.
ITP is a fairly common blood disorder that both children and adults can develop.
There are 2 forms of ITP:
- Acute thrombocytopenic purpura. This is the most common
type of ITP and mainly affects younger children. Less commonly, it may occur in older
children and adults. Symptoms often appear after a virus, such as chickenpox. Acute
ITP often starts suddenly. Symptoms may go away in less than 6 months, often within a
few weeks. Treatment is often not needed. The disorder often does not come back.
Acute ITP is the most common form of the disorder.
- Chronic thrombocytopenic purpura. This disorder can happen
at any age. Symptoms can last from 6 months to several years. Or they may last for
your whole life. Adults have this type more often than children do, but it does
affect teens. Women have it more often than men. Chronic ITP can go away and come
back often. You must have ongoing follow-up care with a blood specialist
What causes immune thrombocytopenic purpura?
With ITP, your immune system attacks your body's own platelets by mistake. Most often this is a result of antibody production against platelets. In a small number of cases, a type of white blood cell called T-cells will directly attack platelets. This immune system mistake may happen due to any of the following:
- Medicines (including over-the-counter medicines) can cause an allergy that cross-reacts with platelets.
- Infections can set off the immune
reaction that leads to ITP. These are often viral infections, including the viruses
that cause chickenpox, hepatitis C, and AIDS.
- Immune disorders, such as rheumatoid arthritis and lupus
- Low-grade lymphomas and leukemias may
make abnormal antibodies that attack platelets.
Sometimes the cause of ITP is not known.
What are the symptoms of immune thrombocytopenic purpura?
A normal platelet count is about 150,000 to 450,000. With ITP, the platelet count is less than 100,000. By the time major bleeding occurs, you may have a platelet count of less than 10,000. The lower your platelet count, the greater your risk of bleeding.
Because platelets help stop bleeding, ITP symptoms are linked to increased bleeding. But each person’s symptoms may vary. Symptoms may include:
- Bruising or purple areas on the skin. These bruises (called purpura) are caused by bleeding under the skin. When you have ITP, bruises may occur for no known reason. They can appear at elbow and knee joints just from movement.
- Tiny red dots under the skin that are due to very small bleeds.
- Bleeding in your mouth, or in and around your gums
- Heavy menstrual periods
- Blood in your vomit, urine, or stool
- Bleeding in your head. This is the most dangerous symptom of ITP.
A head injury that occurs when you don’t have enough platelets to stop the bleeding
can be deadly.
ITP symptoms may look like other health problems. Always see your healthcare provider for a diagnosis.
How is immune thrombocytopenic purpura diagnosed?
Your healthcare provider will take
your health history and give you a physical exam. Your provider may ask about any
medicines you are taking that may cause bleeding or lower your platelet count. You may
also have these tests:
- Complete blood count (CBC). This checks the number of red blood cells, white blood cells, and platelets in your blood. With ITP, the red and white blood cell counts will be normal, but the platelet count will be low.
- Peripheral blood smear. This is a follow-up test to an abnormal CBC. It checks different types of blood cells, in particular platelets for ITP.
- Other blood and urine tests. These tests are done to measure
bleeding time and find possible infections.
How is immune thrombocytopenic purpura treated?
Treatment will depend on your symptoms, age, and general health. It
will also depend on how severe the condition is.
When treatment is needed, the 2
most common forms of immediate treatment are steroids and intravenous immunoglobulin
- Steroids. These medicines help prevent bleeding by slowing
down platelet destruction. They can lead to a higher platelet count in 2 to 3 weeks.
Side effects may include feeling grouchy, stomach irritation, weight gain, high blood
pressure, and acne.
- Intravenous immunoglobulin (IVIG). Intravenous
immunoglobulin (IVIG) is made of antibodies removed from blood donations from
thousands of healthy donors. IVIG helps by increasing your platelet count. You may
see a response in as little as 24 to 48 hours.
Other treatments for ITP may
- Rh immune globulin. This medicine briefly stops the spleen
from destroying platelets. You must be Rh positive and have a spleen for this
medicine to work.
- Medicine changes. If your provider thinks a certain
medicine is the cause, you may need to stop or change that medicine.
- Treating infection. If an infection is causing ITP, then
treating the infection may help increase your platelet count.
- Surgery to remove the spleen (splenectomy). The spleen
makes antibodies that help fight infections. When you have ITP, these antibodies
destroy platelets by mistake. This surgery is done more often in people with chronic
ITP to slow down platelet destruction.
- Platelet transfusion. This may be needed if you have
severe bleeding or are about to have surgery.
- Rituximab. This medicine is an antibody made in a lab. It
slows the antiplatelet antibody production.
- Romiplostim and eltrombopag. These medicines stimulate the
bone marrow to make more platelets.
- Lifestyle changes. These can include making sure that you
use protective gear and not doing certain activities.
Key points about immune thrombocytopenic purpura
- ITP is a blood disorder. With this disease, you have a lower amount of platelets than normal in your blood.
- A decrease in platelets can result in easy bruising, bleeding gums, and internal bleeding.
- ITP may happen suddenly and go away in
about 6 months. Or it may be ongoing (chronic) and last for years.
- Treatment options include medicines that can reduce platelet destruction, or help the body make more platelets.
- In some cases, surgery to remove the spleen is needed.
Tips to help you get the most from a visit to your healthcare provider:
- Know the reason for your visit and what you want to happen.
- Before your visit, write down questions you want answered.
- Bring someone with you to help you ask questions and remember what your provider tells you.
- At the visit, write down the name of a new diagnosis, and any new medicines, treatments, or tests. Also write down any new instructions your provider gives you.
- Know why a new medicine or treatment is prescribed, and how it will help you. Also know what the side effects are.
- Ask if your condition can be treated in other ways.
- Know why a test or procedure is recommended and what the results could mean.
- Know what to expect if you do not take the medicine or have the test or procedure.
- If you have a follow-up appointment, write down the date, time, and purpose for that visit.
- Know how you can contact your provider if you have questions.
Online Medical Reviewer:
L Renee Watson MSN RN
Online Medical Reviewer:
Richard LoCicero MD
Date Last Reviewed:
© 2000-2018 The StayWell Company, LLC. 800 Township Line Road, Yardley, PA 19067. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.